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Antiinflammatory effects of Epimedium brevicornum water extract on lipopolysaccharide‐activated RAW264.7 macrophages
Author(s) -
Yuk SangSuk,
Lim EunMee,
Lee Ji Young,
Lee YoungJong,
Kim YoonSang,
Lee Tae Hee,
Park Seong Kyu,
Bae Hyunsu,
Kim Hyung Min,
Ko SeongGyu,
Oh Myung Sook,
Park Wansu
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3161
Subject(s) - epimedium , lipopolysaccharide , pharmacology , nitric oxide , cytokine , chemokine , chemistry , monocyte , proinflammatory cytokine , traditional medicine , medicine , immunology , endocrinology , inflammation , herb , medicinal herbs
Epimedium brevicornum Maxim (Berberidaceae) possesses estrogenic properties. It is one of the most widespread herbal remedies used in Oriental medicine. The present study investigated the effects of Epimedium brevicornum water extract (EB) on proinflammatory mediators secreted from lipopolysaccharide (LPS)‐induced RAW264.7 macrophages. EB significantly inhibited the production of nitric oxide (NO), interleukin (IL)‐3, IL‐10, IL‐12p40, interferon‐inducible protein‐10, keratinocyte‐derived chemokine, vascular endothelial growth factor, monocyte chemotactic protein‐1 and granulocyte macrophage‐colony stimulating factor in LPS‐induced RAW264.7 cells at concentrations of 25, 50, 100 and 200 μg/mL ( p < 0.05). These results suggest that EB has antiinflammatory activity related to its inhibition of NO, cytokine, chemokine and growth factor production in macrophages. Copyright © 2010 John Wiley & Sons, Ltd.