Antibacterial activity of flavonoids from the stem bark of  Erythrina caffra  thunb. | Zendy

Chukwujekwu J. C. | Zendy; Van Heerden F. R. | Zendy; Van Staden J. | Zendy

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Antibacterial activity of flavonoids from the stem bark of Erythrina caffra thunb.

Author(s) -

Chukwujekwu J. C.,

Van Heerden F. R.,

Van Staden J.

Publication year - 2011

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.3159

Subject(s) - antibacterial activity , traditional medicine , chemistry , minimum inhibitory concentration , bacteria , bark (sound) , pharmacognosy , antimicrobial , biological activity , biology , organic chemistry , biochemistry , in vitro , medicine , ecology , genetics

The antibacterial activity of the stem bark of Erythrina caffra Thunb. was investigated against different bacterial strains. The antibacterial activity was determined by a micro broth dilution assay. Antibacterial compounds were isolated and identified using a Bruker Avance III LPO NMR spectrometer. Four known flavonoids, abyssione‐V 4′‐ O ‐methyl ether, 6,8‐diprenylgenistein, alpinumisoflavone and burttinone, were isolated. All the compounds were active against both Gram‐negative and Gram‐positive bacteria. The minimum inhibitory concentration values obtained (MIC) ranged from 3.9 μg/mL to 125 μg/mL. This is the first report of antibacterial activity of burttinone and the isolation of these compounds from E. caffra . Copyright © 2010 John Wiley & Sons, Ltd.

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