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Antibacterial activity of flavonoids from the stem bark of Erythrina caffra thunb.
Author(s) -
Chukwujekwu J. C.,
Van Heerden F. R.,
Van Staden J.
Publication year - 2011
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3159
Subject(s) - antibacterial activity , traditional medicine , chemistry , minimum inhibitory concentration , bacteria , bark (sound) , pharmacognosy , antimicrobial , biological activity , biology , organic chemistry , biochemistry , in vitro , medicine , ecology , genetics
The antibacterial activity of the stem bark of Erythrina caffra Thunb. was investigated against different bacterial strains. The antibacterial activity was determined by a micro broth dilution assay. Antibacterial compounds were isolated and identified using a Bruker Avance III LPO NMR spectrometer. Four known flavonoids, abyssione‐V 4′‐ O ‐methyl ether, 6,8‐diprenylgenistein, alpinumisoflavone and burttinone, were isolated. All the compounds were active against both Gram‐negative and Gram‐positive bacteria. The minimum inhibitory concentration values obtained (MIC) ranged from 3.9 μg/mL to 125 μg/mL. This is the first report of antibacterial activity of burttinone and the isolation of these compounds from E. caffra . Copyright © 2010 John Wiley & Sons, Ltd.