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A new and weakly antispasmodic protoberberine alkaloid from Rhizoma Coptidis
Author(s) -
Zhao Ming,
Xian YanFang,
Ip SiuPo,
Fong Harry HS,
Che ChunTao
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3154
Subject(s) - antispasmodic , alkaloid , traditional medicine , pharmacognosy , chemistry , medicine , stereochemistry , biological activity , in vitro , biochemistry
A new protoberberine alkaloid, 3‐hydroxy‐2‐methoxy‐9,10‐methylenedioxy‐8‐oxo‐protoberberine, along with three known compounds, was isolated from Rhizoma Coptidis. The new compound displayed weak antispasmodic activity against acetylcholine‐induced contraction in isolated guinea‐pig ileum with an IC 50 of 83.7 μ m . Copyright © 2010 John Wiley & Sons, Ltd.