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Chronic effect of ferulic acid from Pseudosasa japonica leaves on enhancing exercise activity in mice
Author(s) -
You Yanghee,
Kim Kyungmi,
Yoon HoGeun,
Lee KwangWon,
Lee Jeongmin,
Chun Jiyeon,
Shin DongHoon,
Park Jeongjin,
Jun Woojin
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3152
Subject(s) - ferulic acid , antioxidant , lipid peroxidation , abts , dpph , chemistry , oxidative stress , biochemistry , japonica , pharmacology , food science , medicine , botany , biology
Ferulic acid derived from Pseudosasa japonica leaves, which possessed antioxidative potentials with DPPH‐ (54%) and ABTs‐ (65%) radical scavenging activities, and lipid‐peroxidation inhibitory activity (71%), was orally administered to mice for 12 days in order to investigate its effects on exercise endurance capacity and alterations of antioxidant defense systems. Exhaustive swimming time was increased in the ferulic acid‐supplemented group compared with the control group on days 6 and 12 (1.7‐ and 1.8‐fold, respectively). When the mice were exhaustively exercised for 2 consecutive days, a high decrease (53%) was shown in the control group, but no change was found in the ferulic acid‐treated group. The administration of ferulic acid significantly protected the depletion of enzymatic‐ and non enzymatic‐antioxidants due to exhaustive exercise. Also, lipid‐peroxidation levels decreased in the ferulic acid‐treated group compared with the non exercised‐ and control‐groups. These results suggest that ferulic acid from Pseudosasa japonica leaves has a chronic effect on endurance exercise capacity, which is attributed to its ability to ameliorate oxidative stress by improving antioxidant potentials. Copyright © 2010 John Wiley & Sons, Ltd.