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Fatty acid synthase inhibitory activity of dibenzocyclooctadiene lignans isolated from Schisandra chinensis
Author(s) -
Na MinKyun,
Hung Tran Manh,
Oh Won Keun,
Min Byung Sun,
Lee Seung Ho,
Bae KiHwan
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3149
Subject(s) - schisandra , schisandra chinensis , fatty acid synthase , inhibitory postsynaptic potential , traditional medicine , biochemistry , fatty acid , chemistry , atp synthase , biology , stereochemistry , medicine , enzyme , traditional chinese medicine , alternative medicine , pathology , neuroscience
Inhibition of fatty acid synthase (FAS) has been proposed to be a new therapeutic target for the treatment of cancer and obesity. In our preliminary screening study on the FAS inhibitory activity, a n ‐hexane soluble fraction prepared from the fruit of Schisandra chinensis (Schisandraceae) was found to inhibit FAS activity at 100 μg/mL. Nine dibenzocyclooctadiene lignans were isolated from the active fraction and were evaluated for their inhibitory effect on FAS for the first time. The compounds possessing a benzoyl or tigloyl group in the dibenzocyclooctadiene skeleton entirely inhibited the FAS activity in a dose dependent manner. The findings may be partially related to the anticancer effect of the medicinal plant, suggesting a further study on the anticancer potential of dibenzocyclooctadiene derivatives. Copyright © 2010 John Wiley & Sons, Ltd.