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Eriobotrya japonica improves hyperlipidemia and reverses insulin resistance in high‐fat‐fed mice
Author(s) -
Shih ChunChing,
Lin ChengHsiu,
Wu JinBin
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3143
Subject(s) - endocrinology , insulin resistance , medicine , adipose tissue , hyperinsulinemia , hypertriglyceridemia , white adipose tissue , hyperlipidemia , peroxisome , eriobotrya , fatty acid synthesis , triglyceride , fatty acid , chemistry , biology , insulin , diabetes mellitus , japonica , biochemistry , cholesterol , receptor , botany
The effect of Eriobotrya japonica Lindl. (loquat) on insulin resistance was examined in mice fed a high‐fat (HF) diet. First, the mice were divided randomly into two groups: the control (CON) group was fed a low‐fat diet, whereas the experimental group was fed with a 45% HF diet for 10 weeks. After 6 weeks of induction, the HF group was subdivided into five groups and was given orally loquat or not for 4 weeks afterward. It was demonstrated that loquat was effective in ameliorating the HF diet‐induced hyperglycemia, hyperleptinemia, hyperinsulinemia and hypertriglyceridemia, as well as in decreasing the levels of free fatty acid (FFA), but increasing the adipose PPARγ (peroxisomal proliferator‐activated receptor γ) and hepatic PPARα mRNA levels. Loquat significantly decreased the body weight gain, weights of white adipose tissue and visceral fat accompanying the suppressed leptin mRNA levels. Loquat not only suppressed the hepatic mRNA levels of enzymes involved in fatty acid and triacylglycerol synthesis and lowered the sterol regulatory element binding protein‐1c (SREBP‐1c) mRNA level, but also affected fatty acid oxidation enzyme levels. These regulations may contribute to triacylglycerol accumulation in white adipose tissue. The findings provide a nutritional basis for the use of loquat as a functional food factor that may have benefits for the prevention of hyperlipidemia and diabetes. Copyright © 2010 John Wiley & Sons, Ltd.