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Multifunctional cytotoxic agents from Anacardium occidentale
Author(s) -
Kubo Isao,
Nitoda Teruhiko,
Tocoli Felismino E.,
Green Ivan R.
Publication year - 2011
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3109
Subject(s) - anacardium , anacardiaceae , tyrosinase , cytotoxicity , cashew nut , cytotoxic t cell , chemistry , enzyme , melanin , pharmacognosy , biochemistry , biology , traditional medicine , stereochemistry , biological activity , botany , in vitro , food science , medicine , horticulture
The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16‐F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocytes was not suppressed in cultured cells but rather enhanced. Both anacardic acids and cardols exhibited moderate cytotoxicity. Copyright © 2010 John Wiley & Sons, Ltd.