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(‐)‐epigallocatechin‐3‐gallate increases cell proliferation and neuroblasts in the subgranular zone of the dentate gyrus in adult mice
Author(s) -
Yoo KiYeon,
Choi Jung Hoon,
Hwang In Koo,
Lee Choong Hyun,
Lee Soon Ok,
Han SagMyung,
Shin HyungCheul,
Kang IlJun,
Won MooHo
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3083
Subject(s) - subgranular zone , doublecortin , dentate gyrus , neuroblast , neurogenesis , hippocampal formation , cell growth , subventricular zone , biology , endocrinology , medicine , microbiology and biotechnology , stem cell , neural stem cell , biochemistry
Abstract Neurogenesis is regulated by several factors such as age, stress and pharmacological agents. We observed the effects of (‐)‐epigallocatechin‐3‐gallate (EGCG), a major catechin of green tea, on neurogenesis in mice. The animals were orally administered EGCG for 4 weeks. Brain sections were stained using a marker for cell proliferation (Ki67 and BrdU) and neuroblasts (doublecortin, DCX). In all groups, Ki67, BrdU and DCX immunoreaction were observed in the subgranular zone of the dentate gyrus. Oral administration of EGCG significantly increased the number of Ki67‐, BrdU‐ and DCX‐immunoreactive cells as well as BrdU/DCX‐colabled cells in the subgranular zone when compared to those in the vehicle‐treated group. These results indicate that oral administration of EGCG can enhance cell proliferation and increase the number of neuroblasts in mice hippocampal dentate gyrus. Copyright © 2009 John Wiley & Sons, Ltd.