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Antiplasmodial and cytotoxic activity of khellactone derivatives from Angelica purpuraefolia chung
Author(s) -
Chung IllMin,
Ghimire Bimal Kumar,
Kang EunYoung,
Moon HyungIn
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3056
Subject(s) - plasmodium falciparum , rhizome , cytotoxicity , cytotoxic t cell , pharmacognosy , in vitro , stereochemistry , cell culture , lactate dehydrogenase , traditional medicine , ic50 , chloroquine , cancer cell lines , chemistry , biology , biological activity , cancer cell , biochemistry , enzyme , cancer , medicine , immunology , malaria , genetics
The methanolic extract of the rhizomes parts of Agelica purpuraefolia was investigated for its activity against chloroquine‐sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method. Two natural khellactone, (+)‐4′‐Decanoyl‐ cis ‐khellactone (1) and (+)‐3′‐Decanoyl‐ cis ‐khellactone (2) were isolated from the rhizomes parts of A. purpuraefolia. Two compounds were evaluated for in vitro antiplasmodial activities as well as their cytotoxic potential on SK‐OV‐3 cancer cell line cells. Compounds 1, 2 showed notable growth inhibitory activity against chloroquine‐sensitive strains of Plasmodium falciparum with IC 50 values from 1.5 and 2.4 μM. This compound showed no significant cytotoxicity (IC 50 > 100 μM) evaluated using SK‐OV‐3 cancer cell line cells. This is the first report on the antiplasmodial activity of the compounds from A. purpuraefolia. Copyright © 2009 John Wiley & Sons, Ltd.