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Evaluation of Brazilian plants on cancer chemoprevention targets in vitro
Author(s) -
Endringer Denise C.,
Valadares Ydia M.,
Campana Priscilla R. V.,
Campos Jussara J.,
Guimarães Keller G.,
Pezzuto John M.,
Braga Fernão C.
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3050
Subject(s) - ursolic acid , ornithine decarboxylase , traditional medicine , cancer , antioxidant , chemistry , biology , botany , pharmacology , biochemistry , medicine , enzyme , genetics
Cancer is a leading cause of death worldwide. Cancer chemoprevention is one of the promising strategies to decrease its incidence and both plant extracts and natural products may constitute sources of new chemoprevention agents. Some Brazilian species popularly used to treat inflammatory conditions were selected for evaluation for cancer chemoprevention. A total of 32 extracts/fractions from Hancornia speciosa, Davilla elliptica, Jacaranda caroba, Mansoa hirsuta, Remija ferrugina, Solanum paniculatum and Xyris pterygoblephara , along with a mixture of ursolic and oleanolic acids obtained from J. caroba and a dihydroisocoumarin isolated from aerial parts of X. pterygoblephara were tested for their cancer chemoprevention activity [inhibition of 12‐ O ‐tetradecanoyl‐13‐acetate (TPA)‐mediated NF‐κB activation, ornithine decarboxylase (ODC) and cyclooxygenase‐1 (COX‐1); induction of antioxidant response element (ARE)]. Several extracts / fractions were active in more than one assay and those from H. speciosa , M. hirsuta and J. caroba mediated strong responses with NF‐κB, COX‐1 and ARE, respectively. Copyright © 2009 John Wiley & Sons, Ltd.