Premium
The effects of salvianolic acid B from radix salvia miltiorrhizae on the oral pharmacokinetics of metoprolol and metoprolol acid in rats
Author(s) -
Wan RenZhong,
Zhou MaoJin,
Liu ChangXiao
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3030
Subject(s) - metoprolol , pharmacokinetics , oral administration , pharmacology , radix (gastropod) , chemistry , salvia miltiorrhiza , medicine , traditional chinese medicine , biology , botany , alternative medicine , pathology
The present study aimed to investigate the effects of salvianolic acid B (SalB) isolated from Radix Salvia miltiorrhizae on the oral pharmacokinetics of metoprolol (MET) and metoprolol acid (META) in rats. The pharmacokinetic parameters of MET and META were measured after oral (15 mg/kg) administration of MET in rats in the presence and absence of SalB. Compared to the control given MET alone, with the concurrent administration of SalB (50 mg/kg), the AUC and C max of MET increased by 51.7% and 27.7%, and the AUC and C max of META decreased by 26.5% and 19.6%, respectively. With the presence of SalB, the metabolic ratio was markedly decreased by 50.8%. However, no significant changes were observed in the pharmacokinetic parameters of SalB when it was combined with MET. Copyright © 2009 John Wiley & Sons, Ltd.