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Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum
Author(s) -
Tang Jian,
Li HuiLiang,
Shen YunHeng,
Jin HuiZi,
Yan ShiKai,
Liu XiaoHua,
Zeng HuaWu,
Liu RunHui,
Tan YeXiong,
Zhang WeiDong
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3022
Subject(s) - cyclopamine , chemistry , pharmacology , arachidonic acid , ethanol , hedgehog signaling pathway , traditional medicine , biochemistry , biology , medicine , signal transduction , enzyme
Ten steroidal alkaloids – cyclopamine, veratramine, jervine, 3, 15‐diangyloylgermine, 3‐angyloylzygadenine, 3‐veratroyl zygadenine, 15‐veratroylgermine, germine, veratrosine and pseudojervine – from Veratrum dahuricum , together with the ethanol extract and total alkaloids, were evaluated for their antitumor and antiplatelet activities. Cyclopamine, veratramine and germine significantly inhibited the hedgehog pathway in NIH/3T3 cells. Cyclopamine exerted a potent inhibitory effect against the growth of PANC‐1 tumors in mice, with inhibition rates of 40.64%, 44.37%, 46.77% at doses of 5.0, 15.0 and 50.0 mg kg‐1, respectively. Veratroylgermine was found to produce the strongest inhibition against the platelet aggregation induced by arachidonic acid, with inhibition rate of 92.0% at 100 μM. Copyright © 2009 John Wiley & Sons, Ltd.