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Antibiofilm phenylethanoid glycosides from Penstemon centranthifolius
Author(s) -
Ye Miao,
Zhao Yun,
Norman Vanessa L.,
Starks Courtney M.,
Rice Stephanie M.,
Goering Matt G.,
O'NeilJohnson Mark,
Eldridge Gary R.,
Hu JinFeng
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2992
Subject(s) - phenylethanoid , verbascoside , glycoside , iridoid , traditional medicine , chemistry , ethyl acetate , biology , stereochemistry , chromatography , medicine
Bioassay‐guided fractionation of the antibacterial ethyl acetate‐ethanol (50 : 50) extract obtained from the aerial parts of Penstemon centranthifolius led to the isolation of six phenylethanoid glycosides (1–6) and eleven iridoid glycosides (7–17). Their structures were determined on the basis of spectroscopic analysis and comparison with the literature. Among them, two phenylethanoid glycosides, 4″′‐ O –acetylverbascoside (1) and verbascoside (2), were found to show significant inhibition of the formation of bacterial biofilms by Escherichia coli UTI89. Compound 1 showed 77% biofilm inhibition at 2.5 µg/mL, and compound 2 showed 60% inhibition at 5 µg/mL. Copyright © 2009 John Wiley & Sons, Ltd.