Premium
Inhibitory effect of curcumin on motility of human oral squamous carcinoma YD‐10B cells via suppression of ERK and NF‐κB activations
Author(s) -
Shin Hye Kyoung,
Kim Jin,
Lee Eun Ju,
Kim Seong Hwan
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2989
Subject(s) - curcumin , motility , mapk/erk pathway , squamous carcinoma , inhibitory postsynaptic potential , medicine , nf κb , cancer research , basal cell , pharmacology , carcinoma , chemistry , biology , signal transduction , biochemistry , microbiology and biotechnology , inflammation
Abstract Oral squamous cell carcinomas (OSCCs) are characterized by a marked propensity for local invasion, so the identification of agents inhibiting the onset and progression of OSCC has recently gained interest. Here, we found that curcumin inhibited cell proliferation and motility with decreased activities of matrix metalloproteinase (MMP)‐2/9 and decreased mRNA expressions of urokinase‐type plasminogen activator (uPA) and its receptor uPAR in the highly invasive human YD‐10B OSCC cells. Western blot analysis showed that curcumin inhibited the activation of MAP kinases (especially ERK) and NF‐κB, which are involved in the transcriptional regulation of proteolytic enzymes. In conclusion, curcumin is one of the strong phytochemicals with antimotility activity of OSCC; the inhibitory effect of curcumin on the motility of YD‐10B cells could result from its potential to inhibit the activation of ERK/MAP kinase and NF‐κB that consequently down‐regulate the mRNA expressions and activities of proteolytic enzymes such as uPA and MMP‐2/9. Copyright © 2009 John Wiley & Sons, Ltd.