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Vitamin C increases the fecal fat excretion by chitosan in guinea‐pigs, thereby reducing body weight gain
Author(s) -
Jun S. C.,
Jung E. Y.,
Kang D. H.,
Kim J. M.,
Chang U. J.,
Suh H. J.
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2970
Subject(s) - excretion , feces , chitosan , vitamin , weight gain , chemistry , endocrinology , body weight , medicine , biology , food science , biochemistry , microbiology and biotechnology
The aims of this study were to investigate the antiobesity properties of chitosan on its own, as well as in the presence of vitamin C, in vivo . Hartley guinea‐pigs were divided into Control (normal diet), F‐control (high fat diet), Chitosan (high fat diet with 5.0% chitosan) and Chito‐vit C (high fat diet with 5.0% chitosan containing 0.5% vitamin C) groups, respectively. The effects of chitosan, both alone and in the presence of vitamin C, on body weight, total fecal weight, fecal composition and plasma lipid level were studied for 5 weeks. The results of this study indicated that the fat‐binding and water‐holding capacity of chitosan might decrease body weight by reducing the absorption of cholesterol and fat, subsequently increasing total fecal weight, fecal fat excretion and fecal water excretion. Vitamin C increased the fecal fat excretion by chitosan in guinea‐pigs, thereby reducing body weight gain. Copyright © 2010 John Wiley & Sons, Ltd.