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β‐secretase inhibitory effects of furanocoumarins from the root of Angelica dahurica
Author(s) -
Marumoto Shinsuke,
Miyazawa Mitsuo
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2967
Subject(s) - angelica sinensis , pharmacognosy , traditional medicine , furanocoumarin , chemistry , medicine , traditional chinese medicine , in vitro , biochemistry , biological activity , alternative medicine , pathology
In the course of screening antidementia agents from natural products, five β‐secretase (BACE1) inhibitors were isolated from the root extract of Angelica dahurica (Umbelliferae). They were identified as furanocoumarins, isoimperatorin (1), imperatorin (2), (+)‐oxypeucedanin (3), (+)‐byakangelicol (4) and (+)‐byakangelicin (5). Among them, compounds 2 and 4 showed significant inhibitory activity against β‐secretase (BACE1) with IC 50 values of 91.8 ± 7.5 and 104.9 ± 2.4 μ M , respectively. Compounds 1‐5 inhibited BACE1 activity in a dose‐dependent manner. Copyright © 2009 John Wiley & Sons, Ltd.