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Acute toxicity of Schizolobium parahyba aqueous extract in mice
Author(s) -
Mendes Mirian M.,
Vale Luis H. F.,
Lucena Malson N.,
Vieira Sâmela A. P. B.,
Izidoro Luiz Fernando M.,
Junior Robson J. O.,
Soares Andreimar M.,
Alcântara Tânia M.,
Hamaguchi Amélia,
HomsiBrandeburgo Maria Inês,
Rodrigues Veridiana M.
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2956
Subject(s) - toxicity , medicine , acute toxicity , albumin , bilirubin
The herbal extract of Schizolobium parahyba leaves is used commonly in the Brazil central region to treat snakebites. This study evaluates the acute toxicological effects of Schizolobium parahyba aqueous extract in mice 24 h after intraperitoneal administration. Acute toxicity was evaluated using biochemical, hematological and histopathological assays. Alterations in the levels of transaminases, bilirubin, albumin and prothrombrin time were observed, and these are likely to occur due to hepatic injury, which was confirmed by light microscopy. Liver histopathological analysis revealed the presence of lymph plasmocitary inflammatory infiltrate, but no other histopathological alterations were observed in any of the other organs analysed. The data confirm the low toxicity of the extract of Schizolobium parahyba and provide a model for the selection of a dose that does not cause injuries in the organism. Copyright © 2009 John Wiley & Sons, Ltd.