Evaluation of the antiprotozoal activity of neo‐clerodane type diterpenes from  Salvia polystachya  against  Entamoeba histolytica  and  Giardia lamblia | Zendy

Calzada Fernando | Zendy; YepezMulia Lilian | Zendy; TapiaContreras Amparo | Zendy; Bautista Elihú | Zendy; Maldonado Emma | Zendy; Ortega Alfredo | Zendy

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Evaluation of the antiprotozoal activity of neo‐clerodane type diterpenes from Salvia polystachya against Entamoeba histolytica and Giardia lamblia

Author(s) -

Calzada Fernando,

YepezMulia Lilian,

TapiaContreras Amparo,

Bautista Elihú,

Maldonado Emma,

Ortega Alfredo

Publication year - 2010

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2938

Subject(s) - entamoeba histolytica , antiprotozoal , giardia lamblia , biology , traditional medicine , salvia , sage , botany , microbiology and biotechnology , medicine , biochemistry , in vitro , physics , nuclear physics

Chia ( Salvia polystachya Ort., Lamiaceae) is frequently used in Mexican traditional medicine to treat dysentery. In this study the main neo‐clerodane diterpenes (polystachynes A, B and D, as well as linearolactone) were isolated from the aerial parts of chia, and their antiprotozoal activities toward Entamoeba histolytica and Giardia lamblia trophozoites were evaluated in vitro . Linearolactone was the most potent antiamoebic and antigiardial compound with IC 50 values of 22.9 μ M for E . histolytica and 28.2 μ M for G . lamblia . Polystachynes A, B and D, showed moderate antiprotozoal activity against both protozoans with IC 50 values ranging from 117.0 to 160.6 μ M for E . histolytica and from 107.5 to 134.7 μ M for G . lamblia . These data suggest that linearolactone may play an important role in the antidiarrhoeal activity of S . polystachya . Copyright © 2009 John Wiley & Sons, Ltd.

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