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Evaluation of the antiprotozoal activity of neo‐clerodane type diterpenes from Salvia polystachya against Entamoeba histolytica and Giardia lamblia
Author(s) -
Calzada Fernando,
YepezMulia Lilian,
TapiaContreras Amparo,
Bautista Elihú,
Maldonado Emma,
Ortega Alfredo
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2938
Subject(s) - entamoeba histolytica , antiprotozoal , giardia lamblia , biology , traditional medicine , salvia , sage , botany , microbiology and biotechnology , medicine , biochemistry , in vitro , physics , nuclear physics
Chia ( Salvia polystachya Ort., Lamiaceae) is frequently used in Mexican traditional medicine to treat dysentery. In this study the main neo‐clerodane diterpenes (polystachynes A, B and D, as well as linearolactone) were isolated from the aerial parts of chia, and their antiprotozoal activities toward Entamoeba histolytica and Giardia lamblia trophozoites were evaluated in vitro . Linearolactone was the most potent antiamoebic and antigiardial compound with IC 50 values of 22.9 μ M for E . histolytica and 28.2 μ M for G . lamblia . Polystachynes A, B and D, showed moderate antiprotozoal activity against both protozoans with IC 50 values ranging from 117.0 to 160.6 μ M for E . histolytica and from 107.5 to 134.7 μ M for G . lamblia . These data suggest that linearolactone may play an important role in the antidiarrhoeal activity of S . polystachya . Copyright © 2009 John Wiley & Sons, Ltd.