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Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model
Author(s) -
Su ChinCheng,
Yang JaiSing,
Lu ChiCheng,
Chiang JoHua,
Wu ChangLin,
Lin JenJyh,
Lai KuangChi,
Hsia TeChun,
Lu HsuFeng,
Fan MingJen,
Chung JingGung
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2905
Subject(s) - curcumin , in vivo , apoptosis , doxorubicin , pharmacology , lung cancer , in vitro , body weight , cancer , medicine , carcinoma , nude mouse , cancer research , chemistry , chemotherapy , biology , biochemistry , microbiology and biotechnology
Curcumin can decrease viable cells through the induction of apoptosis in human lung cancer NCI‐H460 cells in vitro . However, there are no reports that curcumin can inhibit cancer cells in vivo . In this study, NCI‐H460 lung tumour cells were implanted directly into nude mice and divided randomly into four groups to be treated with vehicle, curcumin (30 mg/kg of body weight), curcumin (45 mg/kg of body weight) and doxorubicin (8 mg/kg of body weight). Each agent was injected once every 4 days intraperitoneally (i.p.), with treatment starting 4 weeks after inoculation with the NCI‐H460 cells. Treatment with 30 mg/kg and 45 mg/kg of curcumin or with 8 mg/kg of doxorubicin resulted in a reduction in tumour incidence, size and weight compared with the control group. The findings indicate that curcumin can inhibit tumour growth in a NCI‐H460 xenograft animal model in vivo . Copyright © 2010 John Wiley & Sons, Ltd.