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Antioxidant activities of coumarins from Korean medicinal plants and their structure–activity relationships
Author(s) -
Thuong Phuong Thien,
Hung Tran Manh,
Ngoc Tran Minh,
Ha Do Thi,
Min Byung Sun,
Kwack Seung Jun,
Kang Tae Suk,
Choi Jae Sue,
Bae KiHwan
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2890
Subject(s) - scopoletin , coumarin , antioxidant , chemistry , umbelliferone , lipid peroxidation , traditional medicine , biochemistry , catechol , stereochemistry , organic chemistry , medicine , alternative medicine , pathology
The aim of this work was to study the structure–activity relationships of the antioxidant activity of natural coumarins isolated from four Korean medicinal plants (1–17) and four purchased coumarins (18–21). The free radical scavenging and lipid peroxidation assays revealed that five phenolic coumarins, scopoletin (1), aesculetin (2), fraxetin (3), umbelliferone (18) and daphnetin (19), possessed considerable antioxidant activities. The coumarins having a catechol group, 2, 3 and 19, showed significant free radical scavenging activity and inhibitory effects on lipid peroxidation, indicating that the catechol group significantly contributed to the antioxidant activities of coumarins. In contrast, the sugar moiety markedly reduced the activities of coumarin glycosides. The results also demonstrate that the α‐pyrone ring of coumarins significantly enhanced the capacity of inhibiting oxidative reactions of coumarins. Copyright © 2009 John Wiley & Sons, Ltd.