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Glabridin inhibits lipopolysaccharide‐induced activation of a microglial cell line, BV‐2, by blocking NF‐κB and AP‐1
Author(s) -
Park Sun Hong,
Kang Jong Soon,
Yoon Yeo Dae,
Lee Kiho,
Kim KangJeon,
Lee Ki Hoon,
Lee Chang Woo,
Moon EunYi,
Han SangBae,
Kim Bong Hee,
Kim Hwan Mook,
Park SongKyu
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2872
Subject(s) - lipopolysaccharide , pharmacology , nitric oxide , tumor necrosis factor alpha , microglia , nf κb , chemistry , cell culture , inflammation , biochemistry , biology , signal transduction , immunology , genetics , organic chemistry
Glabridin, a flavonoid present in licorice root, is known to have antiinflammatory and cardiovascular protective activities. The present study reports an inhibitory effect of glabridin on microglial activation. Glabridin dose‐dependently attenuated lipopolysaccharide (LPS)‐induced production of inflammatory mediators, including nitric oxide, tumor necrosis factor‐α and interleukin‐1β, in BV‐2 cells, a murine microglia cell line. Moreover, mRNA expression of these inflammatory mediators was also suppressed by glabridin in LPS‐stimulated BV‐2 cells. Further study demonstrated that glabridin inhibited LPS‐induced DNA binding activity of NF‐κB and AP‐1 in BV‐2 cells. Collectively, the results presented in this report demonstrate that glabridin inhibits the production of inflammatory mediators in BV‐2 cells and this is mediated, at least in part, by blocking NF‐κB and AP‐1 activation. The results suggest that glabridin might be a potential therapeutic agent for the treatment of neuroinflammatory and neurodegenerative diseases. Copyright © 2009 John Wiley & Sons, Ltd.