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Receptor binding activities of Chlorella on cysteinyl leukotriene CysLT, glutamate AMPA, ion channels, purinergic P 2Y , tachykinin NK 2 receptors and adenosine transporter
Author(s) -
Cheng FongChi,
Feng JinJye,
Chen KuoHsin,
Imanishi Hideyo,
Fujishima Masaki,
Takekoshi Hideo,
Naoki Yo,
Shimoda Minoru
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2864
Subject(s) - ampa receptor , purinergic receptor , chemistry , adenosine , pharmacology , glutamate receptor , receptor , biochemistry , adenosine receptor , inositol , biology , agonist
A Chlorella powder was tested in a total of 129 in vitro receptor binding assay systems. The results showed a potent inhibition of this powder on cysteinyl leukotriene CysLT2, and glutamate AMPA in a dose‐concentration manner with IC 50 mean ± SEM values of 20 ± 4.5 µg/mL and 44 ± 14 µg/mL, respectively. Other moderate and weak activities reflected in competitive binding experiments were seen versus adenosine transporter; calcium channel L‐type, benzothiazepine; gabapentin; kainate, NMDA‐glycine; inositol trisphosphate IP 3 ; cysteinyl CysLT 1 , LTB 4 ; purinergic P 2Y ; tachykinin NK 2 ; serotonin 5‐HT 2B and prostanoid, thromboxane A 2 . Together, the results suggest that the various inhibitory effects of Chlorella powder in these receptor binding assays could reflect its actions in modulating Ca 2+ ‐dependent signal related targets and might be relevant to the mechanisms of its biological effects. These results reveal important potential biochemical activities that might be exploited for the prevention or treatment of several pathologies. From these results, the possible therapeutic usage of the product is discussed. Copyright © 2009 John Wiley & Sons, Ltd.