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Quercetin inhibited murine leukemia WEHI‐3 cells in vivo and promoted immune response
Author(s) -
Yu ChunShu,
Lai KuangChi,
Yang JaiSing,
Chiang JoHua,
Lu ChiCheng,
Wu ChangLin,
Lin JingPin,
Liao ChingLung,
Tang NouYing,
Wood W. Gibson,
Chung JingGung
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2841
Subject(s) - quercetin , in vivo , immune system , spleen , leukemia , biology , flavonoid , apoptosis , pharmacology , immunology , microbiology and biotechnology , biochemistry , antioxidant
Enhanced flavonoid consumption is closely related with a reduced cancer incidence as shown in epidemiological studies. Quercetin (3,5,7,3′,4′‐pentahydroxylflavone) is one of the active components of flavonoids which exist in natural plants, particularly in onions and fruits. It was reported that quercetin induced apoptosis in human cancer cell lines, including human leukemia HL‐60 cells, but there is no available information as to its effects on leukemia cells in vivo . The purpose of the present studies was to focus on the in vivo effects of quercetin on leukemia WEHI‐3 cells. The effects of quercetin on WEHI‐3 cells injected into BALB/c mice were examined. Quercetin decreased the percentage of Mac‐3 and CD11b markers, suggesting that the differentiation of the precursors of macrophages and T cells was inhibited. There was no effect on CD3 levels but increased CD19 levels. Quercetin decreased the weight of the spleen and liver compared with the olive oil treated animals. Quercetin stimulated macrophage phagocytosis of cells isolated from peritoneum. Quercetin also promoted natural killer cell activity. Based on pathological examination, an effect of quercetin was observed in the spleen of mice previously injected with WEHI‐3 cells. Apparently, quercetin affects WEHI‐3 cells in vivo . Copyright © 2009 John Wiley & Sons, Ltd.