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Complement activation by carotenoid derived aldehydes in cultured human vein epithelial cells
Author(s) -
Wu PeiLin,
Lin GuoHua,
Kang XiaoDong,
Yuan Hong,
Shen YueLiang
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2814
Subject(s) - umbilical vein , complement system , carotenoid , alternative complement pathway , classical complement pathway , complement (music) , apoptosis , coronary heart disease , incubation , chemistry , microbiology and biotechnology , in vitro , biology , immunology , biochemistry , medicine , antibody , gene , phenotype , complementation
This study was designed to determine the complement activation effects of carotenoid‐derived aldehydes (CDA) on cultured human umbilical vein endothelial cells (HUVEC). A dose‐dependent complement activation upon incubation of HUVEC with CDA was observed. Interestingly, the data showed that the alternative pathway was not activated. In addition, upon CDA treatment a significant number of apoptotic cells was also observed. The results revealed that CDA could activate the complement by way of the classical pathway. The study suggests that high carotenoid supplementation for the treatment of coronary heart disease should be used cautiously. Copyright © 2009 John Wiley & Sons, Ltd.