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Amelioration of adjuvant induced arthritis by apocynin
Author(s) -
Pandey Anjali,
Kour Kiranjeet,
Bani Sarang,
Suri Krishna Avtar,
Satti Naresh Kumar,
Sharma Punita,
Qazi Ghulam Nabi
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2803
Subject(s) - apocynin , proinflammatory cytokine , pharmacology , immune system , chemistry , arthritis , interferon gamma , adjuvant , medicine , immunology , inflammation , biochemistry , nadph oxidase , oxidative stress
The premise of the study was to investigate the antiarthritic potential of apocynin (APO) in Balb/c mice ( in vivo ). The experiment showed a dose‐dependent decrease in oedema and showed a suppression of proinflammatory cytokines such as TNF‐ α and IL‐1 β and mediators such as prostaglandin E 2 (PGE 2 ) and LTB 4 . At oral doses of 0.5, 1.0, 2.0 and 4.0 mg/kg once daily during the course of the experiment, APO induced an inhibition of T cell mediated immune response causing suppression of CD4+ and CD8+ T cells and of intracellular interferon‐gamma (IFN‐ γ ) by flow cytometry in arthritic mice. In parallel there was a dose‐dependent inhibition in vascular permeability causing an inhibition in the migration of leucocytes and exudate volume at the site of the inflammatory reaction. These observations validate the immunoregulatory potential of apocynin. Copyright © 2009 John Wiley & Sons, Ltd.