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Magnolol enhances pentobarbital‐induced sleeping behaviors: possible involvement of GABAergic systems
Author(s) -
Ma Hong,
Kim ChungSoo,
Ma Yuan,
Nam SangYoon,
Kim DongSeon,
Woo SungSick,
Hong JinTae,
Oh KiWan
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2773
Subject(s) - magnolol , pentobarbital , pharmacology , gabaergic , chemistry , glutamate decarboxylase , receptor , medicine , biochemistry , enzyme
This study was performed to investigate whether magnolol enhances pentobarbital‐induced sleeping behaviors through the GABAergic systems. Magnolol prolonged the sleeping time induced by pentobarbital. In addition, magnolol increased chloride influx in primary cultured cerebellar granule cells. The expression of the GABA A receptor α ‐subunit was increased selectively by magnolol, but magnolol had no effect on the abundance of β ‐ or γ ‐subunits. The expression of glutamic acid decarboxylase (GAD) was not influenced by magnolol. It is suggested that magnolol may enhance pentobarbital‐induced sleeping behaviors through the activation of GABAergic systems. Copyright © 2009 John Wiley & Sons, Ltd.