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Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds
Author(s) -
NassiriAsl Marjan,
Hosseinzadeh Hossein
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2761
Subject(s) - vitis vinifera , resveratrol , polyphenol , proanthocyanidin , antimicrobial , traditional medicine , broad spectrum , grape seed , chemistry , biology , botany , antioxidant , pharmacology , medicine , food science , biochemistry , microbiology and biotechnology , combinatorial chemistry
Vitis vinifera , known as the grapevine, is native to southern Europe and Western Asia. Grape seed and skin contain several active components including flavonoids, polyphenols, anthocyanins, proanthocyanidins, procyanidines, and the stilbene derivative resveratrol. Grape seed extract in particular has been reported to possess a broad spectrum of pharmacological and therapeutic effects such as antioxidative, anti‐inflammatory, and antimicrobial activities, as well as having cardioprotective, hepatoprotective, and neuroprotective effects. Thus, the present review attempts to give a short overview on the pharmacological, toxicological, and clinical studies of grape and its active components. Copyright © 2009 John Wiley & Sons, Ltd.