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Therapeutic advantages of medicinal herbs fermented with Lactobacillus plantarum , in topical application and its activities on atopic dermatitis
Author(s) -
Joo Seong Soo,
Won Tae Joon,
Nam Sang Yoon,
Kim YunBae,
Lee Young Chul,
Park SoYong,
Park Hee Yong,
Hwang Kwang Woo,
Lee Do Ik
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2758
Subject(s) - splenocyte , atopic dermatitis , pharmacology , lactobacillus plantarum , in vivo , immune system , medicine , immunoglobulin e , h&e stain , traditional medicine , immunology , chemistry , lactic acid , biology , immunohistochemistry , antibody , microbiology and biotechnology , bacteria , genetics
The use of herbal medicines in the therapeutic treatment of atopic dermatitis (AD) has been suggested recently. The present study examined whether selected herbal extracts fermented in Lactobacillus plantarum (FHE) possessed anti‐AD properties. In addition, the study assessed the increased bioavailability of these herbal extracts both in vitro and in vivo . The data from these experiments revealed that FHE inhibited the proliferation of splenic T and B cells in a dose‐dependent manner, when activated with their mitogens. Moreover, the expression of Th1/Th2 mRNA cytokines (IL‐2, IL‐4, IL‐5, IL‐13) from mouse splenocytes was inhibited severely as was cyclosporine A. Furthermore, the release of β ‐hexosaminidase in RBL‐2H3 mast cells was suppressed significantly. FHE also reduced the plasma level of IgE in dust mite extract‐induced AD‐like NC/Nga mice. More dramatic results were found in the histological changes, which were observed by hematoxylin–eosin and toluidine blue staining, as well as in the macroscopic features on dorsal lesions of AD‐like NC/Nga mice. In conclusion, the results presented in this study suggest that FHE may have therapeutic advantages for the treatment of AD due to its increased immune‐suppressive and increased absorptive effects, which were fortified by L. plantarum fermentation. Copyright © 2009 John Wiley & Sons, Ltd.