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Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part II
Author(s) -
CsuporLöffler Boglárka,
Hajdú Zsuzsanna,
Réthy Borbála,
Zupkó István,
Máthé Imre,
Rédei Tamás,
Falkay George,
Hohmann Judit
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2755
Subject(s) - hela , mtt assay , biology , epidermoid carcinoma , pharmacognosy , cytotoxicity , cell culture , cytotoxic t cell , lactuca , asteraceae , traditional medicine , hacat , in vitro , botany , biological activity , biochemistry , cancer , medicine , genetics
The antiproliferative activities of aqueous and organic extracts prepared from 26 Hungarian species of the tribes Cynereae and Lactuceae (Asteraceae) were tested in vitro against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells by using the MTT assay. Of the tested 200 extracts of different plant parts obtained with n ‐hexane, chloroform, 50% methanol and water, 16 extracts displayed noteworthy cell growth inhibitory activity (>50% inhibition at a concentration of 10 µg/mL). The IC 50 values of these extracts were determined, and their direct cytotoxic effects were measured. High differences between the antiproliferative and cytotoxic activities, demonstrating a real cell proliferation inhibitory activity rather than direct killing effects, were found for some Centaurea , Cirsium , Cichorium , Lactuca , Onopordum and Scorsonera extracts. Copyright © 2009 John Wiley & Sons, Ltd.