Improved effect of Pycnogenol ®  on impaired spatial memory function in partial androgen deficiency rat model | Zendy

Hasegawa Noboru | Zendy; Mochizuki Miyako | Zendy

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Improved effect of Pycnogenol ® on impaired spatial memory function in partial androgen deficiency rat model

Author(s) -

Hasegawa Noboru,

Mochizuki Miyako

Publication year - 2009

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2702

Subject(s) - castration , androgen deficiency , hippocampus , androgen , endocrinology , radial arm maze , medicine , memory impairment , testosterone (patch) , morris water navigation task , neuroscience , psychology , working memory , cognition , hormone

The improved effect of Pycnogenol ® on impaired spatial memory function was studied in orchidectomized rats. Endogenous testosterone levels were decreased by approximately one‐half for 3 months after castration. In the radial arm maze, castration significantly impaired working and reference memory function without lowering motor function. Pycnogenol ® increased the NGF content in the hippocampus and cortex, and improved the spatial memory impairment. These observations confirmed that diagnostic accuracy can be improved by Pycnogenol ® in androgen‐deficient rats. Copyright © 2009 John Wiley & Sons, Ltd.

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