Premium
Improved effect of Pycnogenol ® on impaired spatial memory function in partial androgen deficiency rat model
Author(s) -
Hasegawa Noboru,
Mochizuki Miyako
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2702
Subject(s) - castration , androgen deficiency , hippocampus , androgen , endocrinology , radial arm maze , medicine , memory impairment , testosterone (patch) , morris water navigation task , neuroscience , psychology , working memory , cognition , hormone
The improved effect of Pycnogenol ® on impaired spatial memory function was studied in orchidectomized rats. Endogenous testosterone levels were decreased by approximately one‐half for 3 months after castration. In the radial arm maze, castration significantly impaired working and reference memory function without lowering motor function. Pycnogenol ® increased the NGF content in the hippocampus and cortex, and improved the spatial memory impairment. These observations confirmed that diagnostic accuracy can be improved by Pycnogenol ® in androgen‐deficient rats. Copyright © 2009 John Wiley & Sons, Ltd.