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Antihyperglycemic and antioxidative effects of a herbal formulation of Radix Astragali , Radix Codonopsis and Cortex Lycii in a mouse model of type 2 diabetes mellitus
Author(s) -
Chan Judy YuetWa,
Lam FungChun,
Leung PingChung,
Che ChunTao,
Fung KwokPui
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2694
Subject(s) - radix (gastropod) , superoxide dismutase , catalase , reactive oxygen species , antioxidant , diabetes mellitus , codonopsis , medicine , traditional medicine , pharmacology , oxidative stress , chemistry , endocrinology , biology , biochemistry , traditional chinese medicine , botany , pathology , alternative medicine
Abstract There is emerging evidence that the generation of reactive oxygen species (ROS), which leads to dysfunction of pancreatic β ‐cells, is a major factor in the development of type 2 diabetes mellitus. Antioxidation is one of the therapeutic strategies to overwhelm the imbalance in ROS production. In this study, a herbal formulation SR10, comprising Radix Astragali , Radix Codonopsis and Cortex Lycii , was examined for its antidiabetic and antioxidative effects using the diabetic + db /+ db mouse model. The results showed that SR10 was effective in decreasing the blood glucose level in chronic treatment by improving β ‐cell function. The activities and expression of antioxidant enzymes, catalase and superoxide dismutase, were up‐regulated when treated with SR10. Moreover, SR10 treatment did not exhibit any toxic effect to the host. Copyright © 2008 John Wiley & Sons, Ltd.