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Triterpene acids isolated from Lagerstroemia speciosa leaves as α ‐glucosidase inhibitors
Author(s) -
Hou Wenli,
Li Yanfang,
Zhang Qiang,
Wei Xin,
Peng Aihua,
Chen Lijuan,
Wei Yuquan
Publication year - 2009
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2661
Subject(s) - oleanolic acid , triterpene , chemistry , terpene , traditional medicine , biochemistry , medicine , alternative medicine , pathology
The potential antidiabetic activity of ethyl acetate extract of the leaves of Lagerstroemia speciosa (LSL) was investigated by α ‐amylase and α ‐glucosidase inhibition assay. Six pentacyclic triterpenes (oleanolic acid, arjunolic acid, asiatic acid, maslinic acid, corosolic acid and 23‐hydroxyursolic acid) were isolated from LSL. Their structures were determined by spectroscopic analysis and their α ‐glycosidase and α ‐amylase inhibitory activities were investigated. They exhibited no or weak inhibitory activity against α ‐amylase and middle α ‐glucosidase inhibitory activities. Corosolic acid, which shows best bioactivity against α ‐glucosidase (IC 50 = 3.53 µg/mL), contributes most to the α ‐glucosidase inhibitory activity of EtOAc extract. The kinetics of inhibition of corosolic acid was also discussed. Results from this study might provide the scientific evidence for LSL for the treatment of diabetes in traditional medicine. Copyright © 2008 John Wiley & Sons, Ltd.