Cochlospermum planchonii  rhizome extract with hepatoprotective activity inhibits cytochrome P‐450 monooxygenases | Zendy

Aliyu Roseline | Zendy; Okoye Z. S. C. | Zendy; Shier W. Thomas | Zendy

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Cochlospermum planchonii rhizome extract with hepatoprotective activity inhibits cytochrome P‐450 monooxygenases

Author(s) -

Aliyu Roseline,

Okoye Z. S. C.,

Shier W. Thomas

Publication year - 1995

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2650090815

Subject(s) - rhizome , monooxygenase , cytochrome , cytochrome p450 , pharmacology , chemistry , traditional medicine , pharmacognosy , biochemistry , enzyme , biology , medicine , biological activity , in vitro

An aqueous extract of Cochlospermum planchonii rhizomes prepared in the manner used by native medical practitioners in northern Nigeria to treat jaundice protects CCI 4 ‐treated rats from liver damage measured as elevated serum levels of diagnostic enzymes. The extract inhibits cytochrome P‐450 monoxygenases aminopyrine‐ N ‐demethylase and aniline hydroxylase, suggesting a plausible hepatoprotective mechanism.

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