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Cochlospermum planchonii rhizome extract with hepatoprotective activity inhibits cytochrome P‐450 monooxygenases
Author(s) -
Aliyu Roseline,
Okoye Z. S. C.,
Shier W. Thomas
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090815
Subject(s) - rhizome , monooxygenase , cytochrome , cytochrome p450 , pharmacology , chemistry , traditional medicine , pharmacognosy , biochemistry , enzyme , biology , medicine , biological activity , in vitro
Abstract An aqueous extract of Cochlospermum planchonii rhizomes prepared in the manner used by native medical practitioners in northern Nigeria to treat jaundice protects CCI 4 ‐treated rats from liver damage measured as elevated serum levels of diagnostic enzymes. The extract inhibits cytochrome P‐450 monoxygenases aminopyrine‐ N ‐demethylase and aniline hydroxylase, suggesting a plausible hepatoprotective mechanism.