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Comparative hepatoprotective activity of three Phyllanthus species, P. urinaria, P. niruri and P. simplex , on carbon tetrachloride induced liver injury in the rat
Author(s) -
Prakash A.,
Satyan K. S.,
Wahi S. P.,
Singh R. P.
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090813
Subject(s) - phyllanthus , hepatoprotection , carbon tetrachloride , medicine , pharmacology , traditional medicine , chemistry , biochemistry , enzyme , glutathione , organic chemistry
The effect of alcohol extracts of three Phyllanthus species was compared on carbon tetrachloride‐induced (chronic) hepatic damage in rats. Alcohol extracts of P. niruri, P. urinaria and P. simplex were administered orally at three different doses. Statistically significant reversal of the elevated serum levels of transaminases (GOT and GPT) were used as the biochemical indices for hepatoprotection. The results of the study indicated that only the extracts of P. niruri and P. urinaria afforded protection of liver in the chronic model. The hepatoprotective activity of P. urinaria is about 60% in comparison with P. niruri. Therefore, P. urinaria may be considered as a good substitute for P. niruri in cases of liver disorders in actual practice.