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Further antibacterial diterpenes from the bark and leaves of Juniperus procera hochst. ex Endl
Author(s) -
Muhammad Ilias,
Mossa Jaber S.,
AlYahya Mohammed A.,
Ramadan Ahmed F.,
ElFeraly Farouk S.
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090810
Subject(s) - bark (sound) , chemistry , terpene , diterpene , ether , antibacterial activity , stereochemistry , botany , bacteria , biology , organic chemistry , ecology , genetics
The bark of Juniperus procera yielded three antibacterial diterpenoids, (+)‐ E ‐communic acid (1), (+)‐Z‐communic acid (2) and (+)‐totarol (3). Compound 2 exhibited significant activity against Gram‐positive bacteria, while 1 was found to be less active. Compound 3, on the other hand, demonstrated potent activity against Mycobacterium organisms, while its corresponding 3β‐hydroxy‐derivative 4 was found to be inactive. The chromatographic separation of (+)‐Z‐communic acid (2) from (+)‐ E ‐communic acid (1) and those previously unreported spectral data of 1 and 2 are described. In addition, the leaves yielded (+)‐8α‐acetoxyelemol, β‐peltatin A methyl ether and deoxypodophyllotoxin.