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The analgesic‐antiinflammatory extract from Araujia sericifera lacks ulcerogenic activity on stress‐gastric damage model
Author(s) -
Bello R.,
MartínezCuesta M. A.,
Moreno L.,
Esplugues J.,
PrimoYúfera E.
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090718
Subject(s) - analgesic , pharmacology , hexane , anti inflammatory , medicine , traditional medicine , chemistry , chromatography
Abstract The present study evaluates the ulcerogenic activity of the hexane extract from dry fruits of Araujia sericifera in an experimental model of cold‐restraint stress. Treatment of rats with 200 mg/kg (i.p.) of hexane extract did not affect the gastric lesions induced by cold‐restraint stress. However, it was confirmed that a dose of 300 mg/kg (i.p.) of acetylsalicylic acid (ASA) which induced a similar analgesic‐antiinflammatory effect, increased significantly the level of gastric damage. Thus, the hexane extract from the fruits of A. sericifera seems to possess analgesic‐antiinflammatory properties which are not linked to gastrolesive effects.