Effects of  Salvia lavandulifolia  Vahl. ssp.  Oxyodon  extract on pancreatic endocrine tissue in streptozotocin‐diabetic rats | Zendy

Jiménez I. | Zendy; Jiménez J. | Zendy; Gámez M. J. | Zendy; González M. | Zendy; De Medina F. Sánchez | Zendy; Zarzuelo A. | Zendy; Osuna I. | Zendy

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Effects of Salvia lavandulifolia Vahl. ssp. Oxyodon extract on pancreatic endocrine tissue in streptozotocin‐diabetic rats

Author(s) -

Jiménez I.,

Jiménez J.,

Gámez M. J.,

González M.,

De Medina F. Sánchez,

Zarzuelo A.,

Osuna I.

Publication year - 1995

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2650090717

Subject(s) - streptozotocin , glibenclamide , islet , diabetes mellitus , traditional medicine , medicine , endocrine system , endocrinology , phytotherapy , insulin , hormone , alternative medicine , pathology

We have investigated the antidiabetic activity of Salvia lavandulifolia ssp. oxyodon extract on rats pancreotomized by streptozotocin (STZ). At a dose of 10 mg dry residue/kg the extract produced: an increase in Langerhans islet number and size; an increase in pancreatic insulin content. When both Salvia extract (10 mg/kg) and glibenclamide (1 mg/kg) were administered concurrently to STZ‐diabetic rats, a significant decrease in glycaemic level (>40%) and mortality index was achieved.

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