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Effects of Salvia lavandulifolia Vahl. ssp. Oxyodon extract on pancreatic endocrine tissue in streptozotocin‐diabetic rats
Author(s) -
Jiménez I.,
Jiménez J.,
Gámez M. J.,
González M.,
De Medina F. Sánchez,
Zarzuelo A.,
Osuna I.
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090717
Subject(s) - streptozotocin , glibenclamide , islet , diabetes mellitus , traditional medicine , medicine , endocrine system , endocrinology , phytotherapy , insulin , hormone , alternative medicine , pathology
We have investigated the antidiabetic activity of Salvia lavandulifolia ssp. oxyodon extract on rats pancreotomized by streptozotocin (STZ). At a dose of 10 mg dry residue/kg the extract produced: an increase in Langerhans islet number and size; an increase in pancreatic insulin content. When both Salvia extract (10 mg/kg) and glibenclamide (1 mg/kg) were administered concurrently to STZ‐diabetic rats, a significant decrease in glycaemic level (>40%) and mortality index was achieved.