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Effects of Ganoderma lucidum on cellular immunocompetence in γ‐irradiated mice
Author(s) -
Chen WangChi,
Hau DouMong
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090716
Subject(s) - immunocompetence , spleen , splenocyte , body weight , ratón , group b , medicine , immunology , endocrinology , immune system
We have investigated the effects on mice treated with Ganoderma lucidum (GI) when the whole body was exposed to 400 rad γ‐irradiation. The mice were divided into five groups. Group A was the normal control; group B, the experimental control, was treated with GI; group C was the radiation control (RT); group D was treated with RT and GI; group E was treated with GI, RT and GI. The results revealed that the relative spleen weight had increased significantly in groups B and E on day 7 and increased in all experimental groups on day 28 after irradiation. The leukocyte counts decreased obviously in groups C, D and E on day 7, and recovered in groups D and E was faster than that in group C on day 28. The blastogenic response of splenocytes to LPS, Con A and PHA in groups administered GI were higher than that in group C on days 7 and 28. Therefore, GI seemed to assist the recovery of cellular immunocompetence in γ‐irradiated mice.