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Synthesis of [4,5‐ 3 H]‐Exo‐3,6‐epoxyhexahydrophthatic anhydride
Author(s) -
Wu Dezhu,
Zheng Zongqi,
Wang Guangsheng
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090715
Subject(s) - maleic anhydride , furan , catalysis , chemistry , organic chemistry , copolymer , polymer
A convenient two‐step synthesis of [4,5‐ 3 H]‐Exo‐3,6‐epoxyhexahydrophthatic anhydride ((4,5‐ 3 H)‐norcantharidin) consists of furan reacting with maleic anhydride to form dehydronorcantharidin. Then addition of tritium to dehydronorcantharidin with catalyst to form [4,5‐ 3 H]‐norcantharidin. The specific activity and radiochemical purity were 56 Ci/mmol and 98%, respectively.