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Experimental study of the therapeutic effect of You‐Gui‐Wan on hypogonadism in rats
Author(s) -
Zheng Ping Dong,
Mao Zheng Li,
Gong Bin,
Yokozawa Takako,
Oura Hikokichi
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090707
Subject(s) - testosterone (patch) , endocrinology , medicine , atrophy , testicular atrophy
Rats raised on a diet containing 0.5% adenine showed atrophy of the testes and retrogressive degeneration of the convoluted seminiferous tubules. The development of spermatids was suppressed, and the cell count decreased. In these rats, the activity of 3β‐hydroxysteroid dehydrogenase was markedly decreased, and the blood levels of testosterone and oestradiol were also very low. However, in rats that were also given You‐Gui‐Wan, retrogressive degeneration of the testes was milder, and the blood levels of testosterone and oestradiol were higher, indicating the beneficial effects of You‐Gui‐Wan on the histomorphology of the testes.