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Preliminary studies on the hydroalcoholic extract of the root of Cissampelos sympodialis Eichl in guinea‐pig tracheal strips and bronchoalveolar leucocytes
Author(s) -
Thomas G.,
Araújo C. C.,
Agra M. De F.,
Diniz M. De F. F.,
Bachelet M.,
Vargaftig B. B.
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090702
Subject(s) - guinea pig , histamine , carbachol , adenosine , contraction (grammar) , chemistry , ethanol , pharmacology , cyclic adenosine monophosphate , endocrinology , medicine , biochemistry , receptor
The aqueous fraction of the ethanol extract of the root of Cissampelos sympodialis , reduced the spontaneous tone, and inhibited the contractions induced by submaximal concentrations of carbachol, histamine, prostaglandin F 2α and substance P, in guinea‐pig tracheal preparations. The fraction was approximately equipotent to aminophyl‐line and the IC 50 values of the above agents varied from 13.9 to 95.5 μg/mL, depending on the agonist used. In concentrations ranging from 1–100 μg/mL, the fraction also increased the intracellular levels of cyclic adenosine monophosphate in guinea‐pig bronchoalveolar leucocytes. It is proposed that the combined effects on smooth muscles and on leucocytes indicate a pharmacological basis for the use of the plant in asthma.