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Active constituents of the bulbs of Fritillaria ebeiensis and their antitumour activity in mice
Author(s) -
Ping Li,
Guojun Xu,
Luoshan Xu,
Yixian Wang
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090617
Subject(s) - alkaloid , traditional medicine , pharmacognosy , active compound , chemistry , biological activity , active principle , stereochemistry , pharmacology , biology , biochemistry , in vitro , medicine
The crude alkaloid of Fritillaria ebeiensis G. D. Yu et G. Q. Ji, administrated orally at a given dose, showed strong antitumour activity in inhibiting the growth of the solid type of hepatoma in mice. Chemical studies revealed that the active principles in this crude drug were verticine, verticinone and ebeiedine obtained from this species for the first time. This paper deals with the isolation and activity of these principles.