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Anthelmintic and pesticidal activity of Acorus gramineus (Araceae) is associated with phenylpropanoid asarones
Author(s) -
Perrett Sheena,
Whitfield Philip J.
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090604
Subject(s) - araceae , bioassay , anthelmintic , phenylpropanoid , traditional medicine , biology , botany , biochemistry , medicine , ecology , biosynthesis , genetics , enzyme
The hexane extract of the Chinese medicinal plant Acorus gramineus (Araceae) has previously been shown to possess significant bioactivity towards a range of organisms in in vitro bioassays including digenean, nematode and arthropod targets. In the present study the principal active components in A. gramineus were identified as the phenylpropanoids α‐ and β‐asarone by comparing TLC, HPLC, UV and bioassay data obtained using the hexane extract with those derived with commercially available pure compounds. The known mammalian toxicity and carcinogenicity of asarones means that they are unlikely to have any utility as lead compounds for the development of practical anthelmintics and insecticides.