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Palbinone, a novel terpenoid from Paeonia albiflora : A potent inhibitory activity on human monocyte interleukin‐1β
Author(s) -
Kadota Shigetoshi,
Basnet Purusotam,
Terashima Satoshi,
Li JianXin,
Namba Tsuneo,
Kageyu Akira
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090515
Subject(s) - monocyte , terpenoid , nicotinamide , biochemistry , nicotinamide adenine dinucleotide phosphate , nicotinamide adenine dinucleotide , inhibitory postsynaptic potential , chemistry , acetylation , dehydrogenase , biology , enzyme , nad+ kinase , immunology , endocrinology , oxidase test , gene
Palbinone, a novel terpenoid from the roots of Paeonia albiflora , has a very strong inhibitory activity on the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) linked 3α‐hydroxysteroid dehydrogenase (3α‐HSD) of rat liver cytosol and showed a significant inhibitory activity on human monocyte interleukin‐1β, a polypeptide which is though to play an important role in inflammation. In contrast the enzymes cyclooxygenase (CO), thromboxane A synthase (TX) and 5‐lipoxygenase (LO) were not significantly inhibited by palbinone when it was compared with tenokisicum, indomethacin, imidazole and 2, 3, 5‐trimethyl‐6‐(12‐hydroxy‐5, 10‐dodecadiynyl)‐1, 4‐benzoquinone (AA‐861) as positive controls under similar experimental conditions. The activity of palbinone was highly selective since it inhibited strongly only human monocyte interleukin‐1β and did not show any significant activity on CO, TX and LO.