Premium
Effects of TDEYA from Atractylodes rhizome on experimental gastric ulcer
Author(s) -
Sakurai Tetsuro,
Sugawara Hiroki,
Saito KenIchi,
Kano Yoshihiro
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090507
Subject(s) - pepsin , stomach , mucus , atractylodes , pharmacology , ethanol , medicine , rhizome , gastric mucosa , lesion , oral administration , chemistry , traditional medicine , gastroenterology , biochemistry , pathology , biology , enzyme , ecology , alternative medicine , traditional chinese medicine
The administration of (6E, 12E)‐tetradecadiene‐8, 10‐diyne‐1, 3‐diol diacetate (TDEYA), isolated from Atractylodes rhizome, promoted the transit of charcoal in the small intestine of mice at a dose of 250 mg/kg. TDEYA prevented lesion formation induced by HCl‐ethanol or ethanol in a dose‐dependent manner. This action was still evident following intraperitoneal administration and previous treatment with indomethacin. The protective effect of TDEYA against gastric lesion caused by necrotizing agents would thus appear not to be mediated by endogenous prostaglandins. TDEYA did not inhibit gastric ulcers induced by pyloric ligation nor did it reduce gastric juice output or pepsin activity. TDEYA significantly increased hexosamine content in gastric juice and the mucosa. The effect of TDEYA on HCl‐ethanol or ethanol‐induced gastric lesions may thus be exerted through its protective action on the stomach by secreting mucus and by not reducing gastric juice secretion or pepsin activity.