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Uraemic toxin reduction: A newly found effect of hydrolysable‐type tannin‐containing crude drug and gallotannin
Author(s) -
Yokozawa Takako,
Fujioka Koji,
Oura Hikokichi,
Tanaka Takashi,
aka GenIchiro,
Nishioka Itsuo
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090504
Subject(s) - crude drug , chemistry , toxin , pharmacology , drug , urea , oral administration , creatinine , medicine , chromatography , biochemistry
The levels of urea nitrogen, creatinine, methylguanidine and guanidinosuccinic acid, which accumulate in blood in parallel with the progress of renal failure after adenine administration, were decreased significantly in rats given Galla Rhois, Moutan Cortex or Paeoniae Radix extract. Administration of Galla Rhois extract was found to be more effective than the other two crude drugs in decreasing the uraemic toxin parameters. A uraemic toxin‐decreasing effect similar to that of crude drug was also obtained using 1,3,6‐tri‐ O ‐galloyl‐β‐D‐glucopyranose and 1,2,3,4,6‐penta‐ O ‐galloyl‐β‐D‐glucopyranose.