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Pharmacological activities of extracts of Daniellia oliveri (Rolfe) Hutch. and Dalz. (Leguminosae)
Author(s) -
Onwukaeme N. D.
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090414
Subject(s) - antipyretic , traditional medicine , analgesic , chemistry , ethyl acetate , ileum , pharmacology , medicine , biochemistry
Extracts of the stem bark of Daniellia oliveri using hexane, ethyl acetate and methanol were tested for analgesic, antipyretic and antiinflammatory activities. The hexane extract exhibited a dose related analgesic activity whilst the methanolic extract was active in the induced inflammatory condition. The ethyl acetate extract was relatively inactive and none of the extracts showed any antipyretic activity. Metabolic cage studies showed that a 70% ethanolic extract of the bark caused significant decreases in body weight, food intake, urine and stool output of rats. This extract also exhibited a competitive antagonism on histamine‐induced contractions of the guinea‐pig ileum and a non‐competitive inhibition of acetyl choline‐induced contraction of the frog rectus abdominis muscle.