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Behavioural effects of Visnea mocanera extract: Psychostimulant and anxiogenic properties
Author(s) -
ándezPérez M. Hern,
Mateo C. C. Sánchez,
Darias V.,
Rabanal R. M.
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090413
Subject(s) - anxiogenic , chemistry , pharmacognosy , methanol , pharmacology , elevated plus maze , traditional medicine , anxiolytic , biological activity , biology , medicine , biochemistry , in vitro , anxiety , receptor , organic chemistry , psychiatry
Neuropharmacological studies were conducted in mice with different extracts from the leaves and fruits of Visnea mocanera L. f. (Theaceae). The combined data obtained from all biological models suggest that the methanol extract from the leaves and the syrup from the fruits appear to have a psychostimulant action, since these extracts increased locomotor activity (the methanol extract at 250 mg/kg p.o.), reduced pentobarbital‐induced sleeping time (the methanol extract and syrup at 250 mg/kg p.o.) and produced hyperthermia (the syrup at 250 and 500 mg/kg p.o.). The aqueous fraction (250 and 500 mg/kg p.o.) and syrup (500 mg/kg p.o.) from fruits showed an anxiogenic‐like profile in mice when evaluated acutely in the elevated plus‐maze test.