Antihepatotoxic Effects of chlorogenic acid from  Anthocephalus cadamba | Zendy

Kapil A. | Zendy; Koul I. B. | Zendy; Suri O. P. | Zendy

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Antihepatotoxic Effects of chlorogenic acid from Anthocephalus cadamba

Author(s) -

Kapil A.,

Koul I. B.,

Suri O. P.

Publication year - 1995

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2650090307

Subject(s) - carbon tetrachloride , chlorogenic acid , lipid peroxidation , pharmacology , antioxidant , in vivo , chemistry , liver injury , intraperitoneal injection , in vitro , ccl4 , biochemistry , traditional medicine , medicine , biology , food science , microbiology and biotechnology , organic chemistry

In the present study, chlorogenic acid (CGA) isolated from Anthocephalus cadamba was screened for hepatoprotective activity by in vitro and in vivo assay methods using carbon tetrachloride (CCl 4 ) as a model of liver injury. Intraperitoneal administration of CGA to mice at a dose of 100 mg/kg body weight for 8 days caused significant reversal in lipid peroxidation, enzymatic leakage, cytochrome P450 (Cyt P450) inactivation and produced enhancement of cellular antioxidant defence in CCl 4 ‐intoxicated mice, revealing that the antioxidative action of CGA is responsible for its liver protective activity. CGA exhibited a better therapeutic protective action than silymarin (SM), in CCl 4 ‐administered mice.

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