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Antihepatotoxic Effects of chlorogenic acid from Anthocephalus cadamba
Author(s) -
Kapil A.,
Koul I. B.,
Suri O. P.
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090307
Subject(s) - carbon tetrachloride , chlorogenic acid , lipid peroxidation , pharmacology , antioxidant , in vivo , chemistry , liver injury , intraperitoneal injection , in vitro , ccl4 , biochemistry , traditional medicine , medicine , biology , food science , microbiology and biotechnology , organic chemistry
In the present study, chlorogenic acid (CGA) isolated from Anthocephalus cadamba was screened for hepatoprotective activity by in vitro and in vivo assay methods using carbon tetrachloride (CCl 4 ) as a model of liver injury. Intraperitoneal administration of CGA to mice at a dose of 100 mg/kg body weight for 8 days caused significant reversal in lipid peroxidation, enzymatic leakage, cytochrome P450 (Cyt P450) inactivation and produced enhancement of cellular antioxidant defence in CCl 4 ‐intoxicated mice, revealing that the antioxidative action of CGA is responsible for its liver protective activity. CGA exhibited a better therapeutic protective action than silymarin (SM), in CCl 4 ‐administered mice.