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Evaluation of oestrogenicity and pregnancy interceptory efficacy of lapachol (2‐hydroxy‐3‐(3‐methyl‐2‐butenyl)‐1,4‐naphthoquinone) in the mouse
Author(s) -
Sareen Vineeta,
Jain Sunita,
Narula Anita
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090212
Subject(s) - naphthoquinone , pharmacognosy , chemistry , traditional medicine , medicine , biological activity , organic chemistry , in vitro , biochemistry
Lapachol, a naphthoquinone isolated from Tectona grandis was evaluated for its oestrogenicity and antinidational activity in the mouse and was found to possess a statistically significant ( p < 0.001) uterotrophic effect after administration of the drug at a dose of 20 mg/kg body weight/day/mouse, intramuscularly. However, in comparison with conjugated oestrogen, the drug proved to be a relatively weak oestrogenic. Lapachol when administered at the same dose level exhibited interceptory activity at all stages of early pregnancy.